Clinical Study Shows Mesenchymal Stem Cells Effective in COVID-19 Patients

Clinical Study Shows Mesenchymal Stem Cells Effective in COVID-19 Patients

The novel coronavirus, COVID-19, has caused a global pandemic. People who develop symptoms from COVID-19 have fever (99% of people), fatigue (70% of people) and dry cough (59% of people), and shortness of breath (31% of people). A portion of people—about 20%—will develop COVID-19 pneumonia. About a quarter of people with COVID-19 pneumonia develop life-threatening disease that leads to respiratory failure, shock, and/or multiorgan dysfunction. Sadly, about 2 to 3% of people with COVID-19 die from the disease.

There are no treatments for COVID-19. Because it is a virus, antibiotics do not help. Thus, efforts to use azithromycin or hydroxychloroquine (an anti-malaria drug) will likely be ineffective (though clinical trials are underway). No known anti-viral drug is useful against COVID-19. While a vaccine may one day help provide people with immunity against infection, a COVID-19 immunization is at least a year away.

Mesenchymal stem cells can powerfully modulate immune function, thus, researchers theorized, these stem cells may help a person’s natural immune system fight this horrible virus. To test this hypothesis, scientists in China enrolled 7 patients with COVID-19 pneumonia from Jan 23, 2020 to Feb 16, 2020 and treated them with mesenchymal stem cells. Patients were followed for 14 days after treatment.

Mesenchymal stem cells either cured or significantly improved function in all 7 patients. Lung function and related symptoms significantly improved within 2 days of mesenchymal stem cells treatment. Of the 3 patients in the control group (i.e. patients did NOT receive mesenchymal stem cells), one patient developed acute respiratory distress syndrome, one developed severe COVID-19 pneumonia, and the third one died. Biochemical and blood analyses showed that the treated patients cleared the disease.

These stunning results show that mesenchymal stem cell treatment for COVID-19 is safe and effective in these 7 patients. Hopefully these pioneering researchers continue this work in a greater number of patients or that other researchers (e.g. Italy, United States) expand and replicate these findings. Given that there are no other treatments for COVID-19, the disease is deadly, and mesenchymal stem cells are safe and apparently effective (in a very small clinical study), we hope that others will continue this critical research quickly and efficiently.

Reference: Leng, Z., et al. (2020). Mesenchymal stem cells and immunomodulation: current status and future prospects. Aging & Disease. 2020, Vol. 11 Issue (2): 216-228.

EXCLUSIVE: Chinese doctor claims he made a breakthrough in coronavirus pandemic with stem cell injections – having 100% success rate after treating nine mostly elderly patients.

EXCLUSIVE: Chinese doctor claims he made a breakthrough in coronavirus pandemic with stem cell injections – having 100% success rate after treating nine mostly elderly patients.

Chinese doctor who runs a lab in Wuhan – ground zero of the coronavirus pandemic – claims he could save thousands of lives after making a breakthrough in the treatment of the deadly pathogen, DailyMailTV can reveal.

Dr. Dongcheng Wu, an expert in stem cell therapy, said he has successfully treated nine patients who were hospitalized with novel coronavirus pneumonia.

The patients, mostly elderly, had developed serious breathing issues as well as overwhelming inflammation in their lungs before they volunteered for Dr. Wu’s medical trial earlier this month in Wuhan.

Click here to read more

Australia’s Mesoblast plans to evaluate its stem cell therapy in patients infected with COVID-19

Australia’s Mesoblast plans to evaluate its stem cell therapy in patients infected with COVID-19

PERTH, Australia – Australian stem cell therapy company Mesoblast Ltd. plans to evaluate its allogeneic mesenchymal stem cell (MSC) candidate, remestemcel-L, in patients with acute respiratory distress syndrome (ARDS) caused by coronavirus (COVID-19) in the U.S., Australia, China and Europe.

The company is in active discussions with various governments, regulatory authorities, medical institutions and pharmaceutical companies to implement these activities.

“What people are dying of is acute respiratory distress syndrome, which is the body’s immune response to the virus in the lungs, and the immune system goes haywire, and in its battle with the virus it overreacts and causes severe damage to the lungs,” Mesoblast CEO Silviu Itescu told BioWorld.

Read full news article here

China uses stem cell therapy to treat severe coronavirus cases.

China uses stem cell therapy to treat severe coronavirus cases.

Beijing: Chinese researchers are studying the use of stem cell technology in the treatment of people critically ill with the novel coronavirus disease (COVID-19), according to the Science and Technology Daily.

Four COVID-19 patients who received stem cell treatment while in a serious condition have been discharged from hospital after recovery, and the clinical trial of the therapy will be further expanded, Vice Minister of Science and Technology Xu Nanping, was quoted by the paper as saying.

Stem cells can self-renew or multiply while maintaining the potential to develop into other types of cells. They can become cells of the blood, heart, lungs or other body parts.

Click here to read the news article

Stem Cell Therapy for the Coronavirus

Stem Cell Therapy for the Coronavirus

With the most recent outbreak of the coronavirus, Covid-19, researchers have been working tirelessly to find treatments for the pervasive illness. At the time of publishing, there were 60 total cases in the U.S., but that figure will likely jump due to the illness’s easy transmission and long incubation period.

While experts are diligently working on vaccines and drugs, one surprising treatment has demonstrated efficacy for combatting the illness: stem cell therapy. Find out more about the virus and how stem cell therapy has already helped an infected patient make a remarkable recovery below.

Coronavirus: Fast Facts

While researchers are still learning more about the virus, it appears that Covid-19 can be passed from person-to-person and by touching infected surfaces or objects—similar to how influenza is spread. To complicate matters, experts are finding that the virus spreads easily compared to other illnesses, and has a two- to 14-day incubation period (the time between when the illness is contracted and symptoms appear).

The majority of cases reported thus far have been mild, with symptoms such as cough, fever, and shortness of breath. Yet, approximately 20% of cases become severe, leading to acute respiratory syndrome, kidney failure, and even death. The fatality rate is roughly 2%, which is significantly higher than the 0.1% death rate of the seasonal flu, for instance.

As with most serious illnesses, the coronavirus appears to pose the greatest risk for certain populations, including the infirm and older adults. According to recent findings, stem cell therapy appears to hold promise for treating these populations when they’ve become infected by the coronavirus.

Stem Cell Therapy for Coronavirus

In a new study by Chinese scientists, a 65-year-old woman with diabetes who became seriously ill after contracting the coronavirus made an impressive recovery after receiving stem cell therapy injections. The woman was “fighting for her life” in intensive care at a Chinese hospital almost two weeks after becoming infected.

In a novel treatment approach, the patient received an injection of umbilical cord-derived stem cells. Within four days, she was on back up on her feet again. Previously, she had received antiviral medications and antibiotics, as well as oxygen therapy, which improved her condition but only temporarily. Shortly thereafter, she was admitted to the ICU where her condition continued to worsen, with severe symptoms including organ failure, until her family agreed to begin stem cell therapy.

Stem cell therapy was first suggested as a possible treatment for the severe organ damage caused by Covid-19. It employs the use of powerful, adaptive early-stage cells that have the incredible ability to give rise to multiple types of fully-functioning cells, such as those found in specific types of organs and tissues. Animal testing has shown that stem cell therapy could repair the damage caused by the virus.

Indeed, researchers’ suspicions appear to be true: after experiencing no adverse effects upon receiving the initial dose, the patient received a second shot of stem cells three days later. The next day, she was able to walk with minimal help. Two days after her third and final shot, she left ICU, and her vital signs have since returned to normal. She has also now tested negative for the coronavirus. This case is among 14 others currently testing the use of stem cell therapy for coronavirus treatment.

A doctor in China’s Hunan province says the research confirms stem cell therapy can yield significant results within just three days. He stated that the medical community must be “bold and innovative” in embracing the approach, while other doctors have backed his position, stating that stem cell therapy is “safe and effective.”

While it may be some time before we see stem cell therapy being used to combat deadly virus outbreaks stateside, it’s clear that the treatment could be the antidote to the deadliest cases of the illness, especially for individuals who may be least equipped to fight it.

Call a Stemedix Care Coordinator today for information about treatments available to you at 800-531-0831.

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