Pentosan Polysulfate Sodium and its Effect for Improving Dyslipidemia and Osteoarthritis Knee Pain

Pentosan Polysulfate Sodium and its Effect for Improving Dyslipidemia and Osteoarthritis Knee Pain

Osteoarthritis (OA) is a progressive joint disease that occurs as a result of the cartilage that cushions the bones wearing down over time. Currently, it is estimated that over 500 million people worldwide are affected by OA.  

Clinical OA studies have shown that when the condition is linked to metabolic syndrome, OA often results in more significant joint damage and overall disability. Additionally, these studies have also demonstrated a link between metabolic syndrome and OA, including a higher likelihood of dyslipidemia – an imbalance of lipids including cholesterol, low-density lipoprotein cholesterol, (LDL-C), triglycerides, and high-density lipoprotein (HDL).

In this single-arm, open-label, prospective, non-randomized pilot study, Liu et al. evaluated the efficacy and safety of pentosan polysulfate sodium (PPS) for dyslipidemia and knee OA-related symptoms. 

PPS has exhibited potential treatment benefits for OA in previous studies. Specifically, animal models have shown PPS to reduce cholesterol and triglyceride levels while also exhibiting anti-inflammatory properties. These studies have also demonstrated that PPS demonstrates properties that might be related to the treatment benefit for OA and dyslipidemia and could potentially improve plasma lipid levels, clinical assessments, and cartilage metabolism.

At the conclusion of this study, the authors observed a statistically significant decrease in LDL and a significant reduction in knee OA-related symptoms, including joint-related pain and stiffness.  

The findings of this study showed promising treatment effects of PPS for improving dyslipidemia and clinically observed symptoms related to knee OA (including knee pain, stiffness, and disability). Although this study found that PPS significantly reduced blood levels of total and LDL cholesterol in humans (a finding previously confirmed in animal models), the authors also pointed out that no significant change was found in the primary outcome of triglyceride levels.


While PPS, when administered in a dose of 10 mg/kg, was demonstrated to be safe and well tolerated, the authors point out that this was the first known study investigating the efficacy and safety of oral PPS in people with dyslipidemia and knee OA. 

Liu et al. also highlighted a few limitations of this study, including the small sample size of 38 participants which limited the interpretation of any treatment effect in the context of such variations. Other confounding factors identified in this study included various lifestyle changes that occurred over the course of the 26-week study.

The authors also pointed out that, while significant reductions in pain subscales were observed, the changes were similar in magnitude to changes observed over similar periods on the placebo arm of recent placebo-controlled knee OA pharmacological randomized clinical trials (RCTs).

To further validate the findings of this study, Liu et al. call for a larger RCT with an appropriate control group.

The authors conclude that oral treatment with PPS demonstrated treatment effects to improve dyslipidemia and clinical symptoms related to knee OA and that further studies in this area are necessary.

Source: The effect of pentosan polysulfate sodium for improving … – PubMed.” 7 Feb. 2023, https://pubmed.ncbi.nlm.nih.gov/36879559/.

What Foods Trigger Osteoarthritis?

What Foods Trigger Osteoarthritis?

Arthritis can take away some of your favorite activities and make daily living very uncomfortable or even painful. When it comes to managing this condition, there are certain triggers that you should be aware of. 

Find out what parts of your diet might be contributing to your osteoarthritis symptoms. You can take control of your pain and minimize it once you have this important knowledge. 

The Science Behind Arthritis

There are two main types of arthritis. Rheumatoid arthritis is considered an autoimmune disease and is different from osteoarthritis. On the other hand, osteoarthritis is caused by the breakdown of joint cartilage. 

Your bones are surrounded by a fleshy material called cartilage, which provides them with cushion and flexibility. This is what allows you to move around, bend down, and absorb impact when you’re walking or running. 

Many people call osteoarthritis a “wear and tear” disease because it often results from overuse and strain on your joints. Aging is a leading cause of osteoarthritis — your body can only maintain healthy joints for so long. 

After many long years of movement, your joint cartilage can start to disintegrate. Some people develop bone spurs that harden and cause lots of discomfort. 

Once your bones lose the support and cushion of cartilage, you may experience joint stiffness and pain. Your mobility may suffer, making it hard to complete normal daily activities. Osteoarthritis can be debilitating if left untreated. 

Food, Inflammation, and Osteoarthritis: What’s the Link?

You might be wondering how your diet can affect your joint pain. The things you eat (or don’t eat) can have a strong impact on your overall comfort levels, especially if you struggle with arthritis symptoms regularly. 

Certain foods contain inflammatory compounds that promote swelling and discomfort in your body. If you already suffer from osteoarthritis, this extra inflammation will cause more pain and discomfort, which can worsen existing mobility issues. 

On the other hand, some foods contain anti-inflammatory compounds that help fight inflammation and discomfort. These are the foods you want to regularly incorporate into your diet. 

Learn which foods to avoid if you suffer from osteoarthritis so you can remain comfortable and active around the clock. 

Avoid High-Sugar Foods and Drinks

Foods and beverages with high sugar content are known for their pro-inflammatory effects. Refined sugars cause your body to release compounds called cytokines, which have inflammatory effects on your cells and tissues. This can worsen your joint pain from osteoarthritis. 

Additionally, inflammation may contribute to further breakdown of the cartilage between your joints. If you want to protect your health while living with this condition, avoid packaged and processed snacks and drinks that have high sugar content. 

Some examples of high-sugar foods and drinks include:

  • Cookies
  • Candies
  • Cakes
  • Sodas
  • Sweetened coffee drinks
  • Frozen desserts
  • Energy drinks

Avoid these foods to increase your comfort and decrease your osteoarthritis symptoms. 

Simple Carbs: White Bread, Rice, and Other Refined Foods

Along with added sugar, simple carbohydrates are found in many “white” foods. This means that foods like white bread, white rice, and potato chips are loaded with simple carbs that could contribute to worsening symptoms. 

Simple carbohydrates affect your body differently than complex carbs, which are good for your health. Similar to refined sugars, simple carbs have pro-inflammatory effects and can lead to rapid weight gain. The more you weigh, the more pressure your joints have to deal with every day. 

Avoid simple carbs and opt for whole-grain foods like brown rice instead. 

Saturated Fat Causes Weight Gain and Joint Strain

Foods that are high in saturated fats are bad for your health. Many researchers and medical bodies believe that eating a diet high in saturated fats exponentially increases your risk for heart disease, obesity, and diabetes. 

When you eat too much saturated fats, you’re likely consuming more calories than you burn. This can cause you to pack on extra pounds that are detrimental to your health. Excess weight puts strain on your joints and cartilage, which makes osteoarthritis symptoms far worse. 

Opt for healthier fats instead from sources like:

  • Olive oil
  • Fish
  • Yogurt
  • Hummus
  • Avocado
  • Nuts and seeds

These sources of fat will benefit your health and help you avoid debilitating osteoarthritis symptoms. Look into an anti-inflammatory diet to potentially help.

Don’t Overdo the Fast Food and Fried Treats 

Eating fried foods is never good for your heart health, joints, and waistline. While these foods can be enjoyed in moderation, it’s important to prioritize home-cooked meals over fried and fast foods. 

Fast food is often high in simple carbs, saturated fat, and sodium. These compounds contribute to inflammation and weight gain, which, in turn, causes more joint pain and discomfort. Many people with osteoarthritis experience more joint pain and stiffness the day after eating fried and fast foods. 

Instead of eating foods fried in oil, try baking foods like vegetables and fish with a light coating of olive oil spray. This will reduce the amount of calories in your meal and help you avoid fried treats — a win-win situation for your joint health. 

Limit Your Dairy Intake 

Dairy has been a part of the standard American diet for many years. However, eating too much dairy in one sitting can spell bad news for your health. Osteoarthritis can flare up if you eat excessive amounts of dairy from low-quality sources. 

When dairy is mass-produced, it goes through a process called pasteurization. This process removes many harmful bacteria that can get into raw cow’s milk, but it doesn’t eliminate the inflammatory compounds. 

Human digestive tracts were not originally designed to break down lactose, a key compound in cow’s milk. Other compounds in cow’s milk can worsen your health as well. This means that when you have a condition like osteoarthritis, it’s best to limit your dairy intake. 

Managing Your Life with Osteoarthritis

Making dietary changes can significantly improve your quality of life if you’re living with osteoarthritis. While you can’t always avoid developing this condition, you can live a satisfying life and manage your symptoms. 

If you want to protect your health and reduce the amount of strain on your joints, consider avoiding these common osteoarthritis triggers. 

A Study on Effects of BPC 157 for Multiple Types of Knee Pain

A Study on Effects of BPC 157 for Multiple Types of Knee Pain

Currently, 1 in every 4 adults suffer from chronic knee pain; this represents a 65% increase over the last 20 years. While knee pain can be caused by several causes, including meniscus tears, tendinosis, sprains, rheumatoid arthritis, and lupus, osteoarthritis (OA) remains the most common contributor to this condition. 

In this study, Lee and Padgett evaluate the use of the peptides BPC157 and thymosin-beta-4 (TB4) for the treatment of knee pain. Specifically, as part of this study, 17 patients received peptide therapy consisting of BPC157 or a combination of BPC157 and TB4 injections for their knee pain.

It is estimated that the human body has nearly 300,000 peptides. These peptides consist of chains of amino acids that range from 2 to 100 amino acids in length. One specific peptide, BPC157, when isolated, has demonstrated restorative properties that have helped in the repair of tendons, ligaments, muscles, nerves, and bone fractures. BPC157 has also been found to promote recovery from traumatic brain injury (TBI), reduce blood clots, and protect the liver.

Because of its reported acceleration of recovery from ruptured tendons, BPC157 has also become a favored therapeutic option by athletes looking to speed up the healing of their injuries. Prior to this study, no study using BPC157 in humans has been published, nor has this peptide received US Food and Drug Administration (FDA) approval in the United States.

TB4 is FDA-approved and a naturally occurring peptide that originates in the thymus gland. TB4 possesses a range of healing and regenerative properties, including accelerating recovery from skin wounds, TBI, stroke, and multiple sclerosis. TB4 has also been shown to reduce inflammatory markers and pain.

The patients involved in this study either received only an intra-articular injection of BPC157 or a combination of both BPC157 and TB4 injections. 

As a follow-up, and as part of this retrospective study, the author followed up with patients between 6 months and 1 year after receiving peptide injections in their knee. Of those receiving only the intra-articular injection of BPC157, 91.6% reported significant improvements in knee pain while 75% of patients who received both peptides showed significant improvement. 

While treating knee pain with BPC157 and TB4 has demonstrated potential for future therapeutic options, the author calls for additional larger studies to better understand improvements in structural changes and increased collagen production in patients with OA-induced knee pain.

Lee concludes that this retrospective study demonstrates that BPC157 has been shown to help reduce knee pain and have prolonged effects lasting over six months, a significant benefit when compared to the documented short-lived results of steroid treatment. Source: “Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.” https://pubmed.ncbi.nlm.nih.gov/34324435/

Cartilage Repair with Mesenchymal Stem Cells in Osteoarthritis

Cartilage Repair with Mesenchymal Stem Cells in Osteoarthritis

Osteoarthritis (OA) is the most common and widespread form of arthritis, affecting an estimated 655 million people worldwide. Occurring as a result of cartilage degeneration, OA is a progressive degenerative disorder that most commonly affects the joints of the hands, hips, knees, and spine.  

Although OA can affect anyone, it is most commonly observed in older patients. In fact, all individuals over the age of 65 are believed to demonstrate some clinical or radiographic evidence of OA.  

While surgical and pharmaceutical treatment options for OA exist as a way to manage the symptoms and progression of the disease, treatment for the restoration of normal cartilage function has yet to be achieved.

Considering the tissue of joint cartilage is composed primarily of chondrocytes found in bone marrow-derived mesenchymal stem cells (BMSCs), using these specific stem cells appears to have significant potential for use in the therapeutic regeneration of cartilage. 

In this review, Gupta et al. evaluate the advances in using BMSCs and their therapeutic potential for repairing cartilage damage in OA. Evaluating current research, the authors point out that one of the key characteristics of MSCs, including BMSCs, is that they are generally hypoimmunogenic and possess immunosuppressive activity, suggesting that BMSCs could be used as allogeneic applications for cartilage repair.  

Preclinical models of OA have also demonstrated that the effects of MSC transplantation have been effective for cartilage repair. Additionally, clinical models have reported on the safety and positive therapeutic effects of MNSC administration in patients with OA. 

The authors point out that while the exact mechanism by which BMSCs regenerate articular cartilage in patients with OA is not clear, their ability to induce proliferation and tissue-specific differentiation appears to aid in the repair of damaged cartilage.

The ability of BMSCs to migrate and engraft onto multiple musculoskeletal tissues and differentiate at the site of injury while demonstrating anti-inflammatory and immunosuppressive properties demonstrate their potential as a therapeutic treatment for degenerative diseases like OA. 

While the information provided in this review demonstrates the potential of BMSCs to support treatment and recovery from the damage caused because of OA, Gupta et al. call for additional clinical studies to assess the curative properties and long-term outcome of using MCSCs for the treatment of OA before they can be used routinely as a clinical treatment for the condition.

Source: “Mesenchymal stem cells for cartilage repair in osteoarthritis – PMC.” 9 Jul. 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580463/.

Role of Mesenchymal Stem Cells in Osteoarthritis Treatment

Role of Mesenchymal Stem Cells in Osteoarthritis Treatment

Osteoarthritis (OA) is the most common form of arthritis and is estimated to affect over 500 million people worldwide.  A result of the progressive deterioration of the protective cartilage that cushions the ends of the bones, OA most commonly affects the hands, knees, hips, and spine and is characterized by pain, stiffness, and loss of mobility in and around the affected areas.

Without a known way to treat and/or prevent OA from occurring, current conventional treatment of the condition typically involves a combination of prescription and OTC drugs, physical therapy, and lifestyle adjustments in an effort to treat and slow the progression of the symptoms associated with OA.

As the beneficial applications of stem cells continue to emerge, and considering their ability to replace and repair cells and tissues throughout the body, researchers believe that they can be used to treat joint disorders, including OA. The majority of the current stem cell therapies being investigated for use in treating OA use mesenchymal stem cells (MSCs), primarily due to their multilineage differentiation towards cell types in the joints and for their immunoregulatory functions. 

In this review, Kong et al. provide detailed information on OA and MSCs, share updated information on pre-clinical and clinical trials and related applications of MSCs, and discuss additional efforts on cell-based therapy for treating OA and other joint and bone diseases.

Several preclinical models have investigated MSCs in treating OA and have demonstrated success in generating cartilage from MSCs. In addition, several animal models have demonstrated the beneficial effect of MSCs on cartilage, including protecting existing cartilage, repairing defects of joint cartilage, regenerating and enhancing cartilage, and even preventing OA.  

Additionally, there have been several animal models evaluating the effects of intra-articular injection of MSCs for treating OA with researchers noting marked regeneration of tissue and decreased degeneration of articular cartilage.  

Clinical trials using MSCs to treat human joint cartilage defects have found that MSCs could be used to repair cartilage defects, improve joint function, reduce pain, and have demonstrated the potential to use MSC therapy for cartilage repair and regeneration as a way to reduce signs and symptom commonly associated with OA.

Although these studies have demonstrated the tremendous potential associated with the use of MSCs for treating OA, they have also highlighted some potential concerns associated with MSC-based therapy. These concerns include determining the specific number and type of MSCs best suited for treating OA, a better understanding of the timing and delivery strategies for the administration of MSCs, and identifying the stages of disease best suited for MSC therapy.  

Further concerns highlighted by the authors include the potential of genetic influences when using autologous MSC cells for treatment, the potential for the overall quality of MSC cells used in older patients to be too low, and the overall safety of stem cell therapy as a therapeutic treatment option for OA. 

Despite the concerns identified above, Kong et al. conclude that the advancement of regenerative medicine and innovative stem cell technology offers a unique and exciting opportunity to treat OA.  


Source: “Role of mesenchymal stem cells in osteoarthritis treatment – NCBI.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822967/.

Tips to Keep Your Bones Healthy

Tips to Keep Your Bones Healthy

Your bones are essential for providing your body with support and stability, especially as you age. When you get older, you are more susceptible to conditions that can weaken bones and make them more prone to breakage.

Keeping your bones healthy throughout your life will strengthen them in old age and make you less likely to develop conditions like osteoporosis. Take a look at these tips for healthier bones.

Increase Calcium Intake

One of the best ways to strengthen your bones is to increase your calcium intake. Many people are deficient in calcium, and it puts them at a higher risk of osteoporosis and other conditions that weaken bones. You can increase your calcium intake by adding more whole milk, yogurt, and calcium supplements to your diet.

Stay Active

You don’t need to perform strenuous exercises or intense workouts. A daily walk, swimming, or even playing golf are all good ways to remain physically active.

People who lead a sedentary lifestyle tend to have weaker bones than those who get regular exercise. To strengthen your bones and reduce the risk of osteoporosis, you should strive to stay active throughout your whole life. 

Quit Smoking

Research has suggested that smoking cigarettes can increase your risk of bone breakage or developing osteoporosis. To help yourself maintain strong, healthy bones, it’s better to quit smoking as soon as possible.

Decrease Alcohol Consumption

In addition to tobacco products, alcohol can increase your risk of developing osteoporosis. For stronger, healthier bones, you should try to keep your drinking to a minimum.

Keep Hormones in Check

Some instances of weak bones and osteoporosis are linked to hormone imbalances. Getting your hormone levels regularly checked and ruling out thyroid conditions can help you keep strong bones for your entire life.

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